[HTML][HTML] Guidelines for investigating causality of sequence variants in human disease
…, SR Sunyaev, D Valle, BF Voight… - Nature, 2014 - nature.com
The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing
disease-causing sequence variants from the many potentially functional variants present in …
disease-causing sequence variants from the many potentially functional variants present in …
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
Lahars at Merapi volcano, Central Java: an overview
Merapi volcano, in Central Java, is one of the most active volcanoes in the world. At least 23
of the 61 reported eruptions since the mid-1500s have produced source deposits for lahars. …
of the 61 reported eruptions since the mid-1500s have produced source deposits for lahars. …
Biological, clinical and population relevance of 95 loci for blood lipids
…, NJ Wareham, G Waeber, P Vollenweider, BF Voight… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
…, AG Uitterlinden, AM van Rij, BF Voight… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, NR Robertson, V Steinthorsdottir, JP Tyrer, BF Voight… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…