To understand the biology and evolution of ruminants, the cattle genome was sequenced to
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …

Appaloosa horses are predisposed to equine recurrent uveitis ( ERU ), an immune‐mediated
disease characterized by recurring inflammation of the uveal tract in the eye, which is the …

Gene expression as an intermediate molecular phenotype has been a focus of research
interest. In particular, studies of expression quantitative trait loci (eQTL) have offered promise for …

Duchenne muscular dystrophy (DMD) is an X-linked human disorder in which absence of
the protein dystrophin causes degeneration of skeletal and cardiac muscle. For the sake of …

Infection by Theiler’s murine encephalomyelitis virus (TMEV) is a model for neurological
outcomes caused by virus infection because it leads to diverse neurological conditions in mice, …

The expression of a gene can vary across individuals in the general population, as well as
between monozygotic twins. This variable expression is assumed to be due to the influence of …

Human aging is associated with cognitive decline and an increased risk of neurodegenerative
disease. Our objective for this study was to evaluate potential relationships between age …

Host genetic background is a significant driver of the variability in neurological responses to
viral infection. Here, we leverage the genetically diverse Collaborative Cross (CC) mouse …

Background: In Duchenne muscular dystrophy (DMD), abnormal cardiac function is typically
preceded by a decade of skeletal muscle disease. Molecular reasons for differences in …

A wide range of viruses cause neurological manifestations in their hosts. Infection by neurotropic
viruses as well as the resulting immune response can irreversibly disrupt the complex …