[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update
PE Harris, KL Cooper, C Relton… - International journal of …, 2012 - Wiley Online Library
Objectives: To update previous systematic reviews of 12‐month prevalence of complementary
and alternative medicine (CAM) use by general populations; to explore trends in CAM use …
and alternative medicine (CAM) use by general populations; to explore trends in CAM use …
Induction of epigenetic alterations by dietary and other environmental factors
Dietary and other environmental factors induce epigenetic alterations which may have important
consequences for cancer development. This chapter summarizes current knowledge of …
consequences for cancer development. This chapter summarizes current knowledge of …
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
…, W Nystad, GH Koppelman, CL Relton… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
[HTML][HTML] Guidelines for performing Mendelian randomization investigations: update for summer 2023
… For example, a Mendelian randomization analysis for C-reactive protein (CRP) may be
conducted using variants in the neighbourhood of the CRP gene region (which encodes C-…
conducted using variants in the neighbourhood of the CRP gene region (which encodes C-…
[PDF][PDF] Pathogenic mitochondrial DNA mutations are common in the general population
Mitochondrial DNA (mtDNA) mutations are a major cause of genetic disease, but their
prevalence in the general population is not known. We determined the frequency of ten …
prevalence in the general population is not known. We determined the frequency of ten …
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
…, M Imboden, S Huntsman, N Vilor-Tejedor, CL Relton… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …
predominantly in populations of European ancestry. To identify further susceptibility loci for this …
[HTML][HTML] Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies
Mendelian randomization (MR) is an increasingly important tool for appraising causality in
observational epidemiology. The technique exploits the principle that genotypes are not …
observational epidemiology. The technique exploits the principle that genotypes are not …