User profiles for C. Relton

Caroline Relton

- Verified email at bristol.ac.uk - Cited by 31389

Clare Relton

- Verified email at qmul.ac.uk - Cited by 3585

[HTML][HTML] DNA methylation aging clocks: challenges and recommendations

…, JPJ Issa, KT Kelsey, RE Marioni, W Reik, CL Relton… - Genome biology, 2019 - Springer
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update

PE Harris, KL Cooper, C Relton… - International journal of …, 2012 - Wiley Online Library
Objectives: To update previous systematic reviews of 12‐month prevalence of complementary
and alternative medicine (CAM) use by general populations; to explore trends in CAM use …

Induction of epigenetic alterations by dietary and other environmental factors

JC Mathers, G Strathdee, CL Relton - Advances in genetics, 2010 - Elsevier
Dietary and other environmental factors induce epigenetic alterations which may have important
consequences for cancer development. This chapter summarizes current knowledge of …

The MR-Base platform supports systematic causal inference across the human phenome

…, HA Shihab, NJ Timpson, DM Evans, C Relton… - elife, 2018 - elifesciences.org
10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …

[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis

…, W Nystad, GH Koppelman, CL Relton… - The American Journal of …, 2016 - cell.com
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

…, L Milani, P Van Der Harst, A Peters, T Illig, CL Relton… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

[HTML][HTML] Guidelines for performing Mendelian randomization investigations: update for summer 2023

…, C Minelli, JV Morrison, W Pan, CL Relton… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
… For example, a Mendelian randomization analysis for C-reactive protein (CRP) may be
conducted using variants in the neighbourhood of the CRP gene region (which encodes C-…

[PDF][PDF] Pathogenic mitochondrial DNA mutations are common in the general population

HR Elliott, DC Samuels, JA Eden, CL Relton… - The American journal of …, 2008 - cell.com
Mitochondrial DNA (mtDNA) mutations are a major cause of genetic disease, but their
prevalence in the general population is not known. We determined the frequency of ten …

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

…, M Imboden, S Huntsman, N Vilor-Tejedor, CL Relton… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …

[HTML][HTML] Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

…, S Burgess, KH Wade, J Bowden, C Relton… - The American journal of …, 2016 - Elsevier
Mendelian randomization (MR) is an increasingly important tool for appraising causality in
observational epidemiology. The technique exploits the principle that genotypes are not …