Evolutionary rationale for phages as complements of antibiotics

C Torres-Barceló, ME Hochberg - Trends in microbiology, 2016 - cell.com
Antibiotic-resistant bacterial infections are a major concern to public health. Phage therapy
has been proposed as a promising alternative to antibiotics, but an increasing number of …

The disparate effects of bacteriophages on antibiotic-resistant bacteria

C Torres-Barceló - Emerging microbes & infections, 2018 - Taylor & Francis
Faced with the crisis of multidrug-resistant bacteria, bacteriophages, viruses that infect and
replicate within bacteria, have been reported to have both beneficial and detrimental effects …

[HTML][HTML] A Window of Opportunity to Control the Bacterial Pathogen Pseudomonas aeruginosa Combining Antibiotics and Phages

C Torres-Barceló, FI Arias-Sánchez, M Vasse… - PloS one, 2014 - journals.plos.org
… Phage-containing supernatants were carefully recovered and stored at 4C. This LUZ7 stock
… to 250 µL of media containing ancestral phage (c 10 5 phages) and OD recorded after 24 h. …

[HTML][HTML] Evaluating evolutionary models of stress-induced mutagenesis in bacteria

RC MacLean, C Torres-Barceló, R Moxon - Nature Reviews Genetics, 2013 - nature.com
Increased mutation rates under stress allow bacterial populations to adapt rapidly to
stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced …

[HTML][HTML] Phage therapy faces evolutionary challenges

C Torres-Barceló - Viruses, 2018 - mdpi.com
Antibiotic resistance evolution in bacteria indicates that one of the challenges faced by phage
therapy is that, sooner or later, bacteria will evolve resistance to phages. Evidently, this is …

The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic

C Torres-Barceló, M Kojadinovic… - … of the Royal …, 2015 - royalsocietypublishing.org
… transferred 1 µl aliquots of −80C glycerol stocks into culture medium lacking antibiotics and
these pre-cultures were incubated overnight at 37C with continuous shaking. Pre-cultures of …

Mitigation of evolved bacterial resistance to phage therapy

C Torres-Barceló, PE Turner, A Buckling - Current Opinion in Virology, 2022 - Elsevier
The ease with which bacteria can evolve resistance to phages is a key consideration for
development of phage therapy. Here, we review recent work on the different evolutionary and …

From Hypo- to Hypersuppression: Effect of Amino Acid Substitutions on the RNA-Silencing Suppressor Activity of the Tobacco etch potyvirus HC-Pro

C Torres-Barcelo, S Martin, JA Daros, SF Elena - Genetics, 2008 - academic.oup.com
RNA silencing participates in several important functions: from the regulation of cell metabolism
and organism development to sequence-specific antiviral defense. Most plant viruses …

[HTML][HTML] Experimental evolution of plant RNA viruses

…, P Carrasco, FM Codoner, S Martin, C Torres-Barceló… - Heredity, 2008 - nature.com
C Torres-Barceló … (c) Correlation between virulence and transmission rate in CMV.
Different symbols represent different CMV genotypes. (From Escriu et al., 2003). … C Torres-Barceló

Long‐term effects of single and combined introductions of antibiotics and bacteriophages on populations of Pseudomonas aeruginosa

C TorresBarceló, B Franzon, M Vasse… - Evolutionary …, 2016 - Wiley Online Library
… infection type, but results such as those reported here suggest promising future research
avenues for understanding and applying combined phage-antibiotics therapies (Torres-Barceló