Advances in the depth and quality of transcriptome sequencing have revealed many new
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …

Mammalian genomes encode numerous natural antisense transcripts, but the function of
these transcripts is not well understood. Functional validation studies indicate that antisense …

The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable of …

Antisense transcription (transcription from the opposite strand to a protein-coding or sense
strand) has been ascribed roles in gene regulation involving degradation of the …

Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…

Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …

Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients,
current methods are rudimentary, and a reliable donor cell source is lacking. We show that …

A DNA sequence encoding a G-protein-coupled receptor was isolated from a mouse genomic
library. The predicted protein is similar in structure to the thrombin receptor and has a …

Neuropeptide Y (NPY)-immunoreactive nerve fibers were numerous around arteries and few
around veins. NPY probably co-exists with noradrenaline in such fibers since chemical or …

Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness.
We demonstrate here that a high-affinity DNA analog, locked nucleic acid (LNA), confers …