Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

Despite their crucial role in health and disease, our knowledge of immune cells within human
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the
etiology of several chronic diseases. Although a common, non-synonymous variant in the IL-…

Human genome wide association studies (GWAS) have recently identified at least four new,
non-MHC-linked candidate genes or gene regions causing type one diabetes (T1D), …

… Once the tenth participant had completed 7 d of follow-up, the clinical Treg and safety data
were extracted from the trial database, and a preplanned interim analysis was carried out by …

Identification of alterations in the cellular composition of the human immune system is key to
understanding the autoimmune process. Recently, a subset of FOXP3 + cells with low CD25 …

OBJECTIVE CTLA4 gene variation associates with multiple autoimmune disorders, including
type 1 diabetes. The CTLA4 susceptibility allele was found to generate decreased levels of …

Background Autoimmune disease-associated variants are preferentially found in regulatory
regions in immune cells, particularly CD4 + T cells. Linking such regulatory regions to gene …

Background Traditionally, the transcriptomic and proteomic characterisation of CD4 + T cells
at the single-cell level has been performed by two largely exclusive types of technologies: …

… Inclusion in an NLM database does not imply endorsement of, or agreement with, the …
Rainbow, 1, 2 Deborah J. Smyth, 2 Meghavi Mashar, 2 Jane Brady, 2 Natalia Savinykh, 2 Xaquin …