Cancer develops through a process of somatic evolution 1 , 2 . Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

High-risk localized prostate cancer (HRLPC) is associated with a substantial risk of
recurrence and disease mortality. Recent clinical trials have shown that intensifying anti-androgen …

Ongoing cancer evolution gives rise to intra-tumour heterogeneity (ITH), which is a major
mechanism of therapeutic resistance and therefore an important clinical challenge. However, …

The International Cancer Genome Consortium (ICGC)’s Pan-Cancer Analysis of Whole
Genomes (PCAWG) project aimed to categorize somatic and germline variations in both coding …

In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these …

Local conditions influence how pollutants will weather in subsurface environments and
sediment, and many of the processes that comprise environmental weathering are dependent …

This thesis seeks to advance the field of microrobotics by leveraging Bayesian principles
and computational tools to design system parameters for information gain and microrobot …

Cancer develops through a continuous process of somatic evolution. Whole genome sequencing
provides a snapshot of the tumor genome at the point of sampling, however, the data …

Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling
of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies …