… DJ Conway and KS Lee were responsible for sequencing and phylogenetic analysis of
results. A Matusop organised and assisted in the gathering of samples and epidemiological data. …

Background . Until recently, Plasmodium knowlesi malaria in humans was misdiagnosed as
Plasmodium malariae malaria. The objectives of the present study were to determine the …

Background RTS,S/AS02 is a pre-erythrocytic malaria vaccine based on the circumsporozoite
surface protein of Plasmodium falciparum fused to HBsAg, incorporating a new adjuvant (…

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Background Malaria is a major cause of morbidity and mortality in Africa. International effort
and funding for control has been stepped up, with substantial increases from 2003 in the …

Individuals living in areas where malaria is endemic are repeatedly exposed to many different
malaria parasite antigens. Studies on naturally acquired antibody-mediated immunity to …

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a …

Plasmodium knowlesi, a malaria parasite originally thought to be restricted to macaques in
Southeast Asia, has recently been recognized as a significant cause of human malaria. …

During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs. Currently
there is limited knowledge of cellular and molecular invasion events, and no established …