Sensation seeking and its biological correlates.
M Zuckerman, MS Buchsbaum, DL Murphy - Psychological Bulletin, 1980 - psycnet.apa.org
Reviews the trait of sensation seeking and the biological phenomena associated with it:
strength of the initial orienting reflex, augmenting vs reducing of the average evoked potential, …
strength of the initial orienting reflex, augmenting vs reducing of the average evoked potential, …
[HTML][HTML] Serotonin transporter: gene, genetic disorders, and pharmacogenetics
DL Murphy, A Lerner, G Rudnick… - Molecular …, 2004 - triggered.stanford.clockss.org
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
Targeting the murine serotonin transporter: insights into human neurobiology
DL Murphy, KP Lesch - Nature Reviews Neuroscience, 2008 - nature.com
Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT)
function in mice have led to the identification of more than 50 different phenotypic changes, …
function in mice have led to the identification of more than 50 different phenotypic changes, …
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
…, S Petri, J Benjamin, CR Müller, DH Hamer, DL Murphy - Science, 1996 - science.org
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated
in anxiety in humans and animal models and is the site of action of widely used uptake-…
in anxiety in humans and animal models and is the site of action of widely used uptake-…
Incidence and early course of retlnonathy of prematurity
…, PK Lewallen, JV McDonald Jr, DL Murphy… - Ophthalmology, 1991 - Elsevier
In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants
weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at …
weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at …
Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking
…, L Li, C Patterson, BD Greenberg, DL Murphy… - Nature …, 1996 - nature.com
Twin and adoption studies suggest that 30 to 60% of the variance in many personality traits
is due to inherited factors. However, there is little knowledge of the number or identity of the …
is due to inherited factors. However, there is little knowledge of the number or identity of the …
[HTML][HTML] Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
…, MA Richter, JL Kennedy, DL Murphy… - The American Journal of …, 2006 - cell.com
A functional serotonin transporter promoter polymorphism, HTTLPR, alters the risk of disease
as well as brain morphometry and function. Here, we show that HTTLPR is functionally …
as well as brain morphometry and function. Here, we show that HTTLPR is functionally …
Organization of the human serotonin transporter gene
…, J Gross, K Strauss, BL Wolozin, DL Murphy… - Journal of Neural …, 1994 - Springer
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized.
The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence …
The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence …
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice
D Bengel, DL Murphy, AM Andrews, CH Wichems… - Molecular …, 1998 - ASPET
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …
Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
…, BJ Martin, MR Kruse, KP Lesch, DL Murphy - Molecular …, 2006 - nature.com
The human serotonin transporter gene (SLC6A4, 5-HTT) possesses several polymorphic
loci that affect its expression or function. Rare gain-of-function coding mutations such as …
loci that affect its expression or function. Rare gain-of-function coding mutations such as …