The notochord is the defining structure of the chordates, and has essential roles in vertebrate
development. It serves as a source of midline signals that pattern surrounding tissues and …

… Stemple, Inês Barroso; The emerging use of zebrafish to model metabolic disease. Dis
Model Mech 1 September 2013; 6 (5): 1080–1088. doi: https://doi.org/10.1242/dmm.011346 …

The availability of the whole genome sequence of many model organisms, combined with
well-established chemical mutagenesis methods and cost-effective high-throughput DNA …

DNA amplification is essential to most nucleic acid testing strategies, but established techniques
require sophisticated equipment or complex experimental procedures, and their uptake …

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been
instrumental in the understanding of invertebrate and plant development. Here, we report the …

Vertebrate gastrulation involves the specification and coordinated movement of large
populations of cells that give rise to the ectodermal, mesodermal and endodermal germ layers. …

We have isolated mammalian neural crest cells using a monoclonal antibody to the low
affinity NGF receptor, and established conditions for the serial propagation of these cells In …

As part of a large-scale mutagenesis screen of the zebrafish genome, we have identified 58
mutations that affect the formation and function of the cardiovascular system. The …

Since the publication of the human reference genome, the identities of specific genes associated
with human diseases are being discovered at a rapid rate. A central problem is that the …

The zebrafish pronephric kidney provides a simplified model of nephron development and
epithelial cell differentiation which is amenable to genetic analysis. The pronephros consists …