Background - As circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly
incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural …

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through
exacerbation of oxidative stress Conf Page 1 1 The common analgesic paracetamol enhances …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …

… Diabetes mellitus which represent a traditional risk factor does not seem to be responsible
here, the climatic and hygienic conditions prevailing in this part of the world could be a …

… Deena MA Gendoo is a postdoctoral research fellow at the Princess Margaret Cancer Centre,
Canada. Her research focuses on translational bioinformatics in multiple cancer types, as …

The DNA demethylating agent 5-aza-2′-deoxycytidine (DAC, decitabine) has anti-cancer
therapeutic potential, but its clinical efficacy is hindered by DNA damage-related side effects …

Background Medulloblastoma (MB) is a highly malignant and heterogeneous brain tumour
that is the most common cause of cancer-related deaths in children. Increasing availability of …

Background Systemic inflammation is involved in the development of acute kidney injury (AKI)
after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin …

Detection of amyloidogenic peptides or domains in proteins is of paramount importance towards
understanding their role in amyloidosis in conformational diseases. This thesis explores …