User profiles for D. W. Morgens
David MorgensUniversity of California, Berkeley Verified email at berkeley.edu Cited by 4388 |
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
…, S Stolzenburg, O Gilan, S Bloor, T Noori, DW Morgens… - Nature, 2017 - nature.com
Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to
subvert T-cell-mediated immunosurveillance 1 , 2 . The success of therapies that disrupt PD-…
subvert T-cell-mediated immunosurveillance 1 , 2 . The success of therapies that disrupt PD-…
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …
genetic studies have linked these cells to the pathogenesis of a growing number of …
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Identification of effective combination therapies is critical to address the emergence of drug-resistant
cancers, but direct screening of all possible drug combinations is infeasible. Here …
cancers, but direct screening of all possible drug combinations is infeasible. Here …
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
DW Morgens, RM Deans, A Li, MC Bassik - Nature biotechnology, 2016 - nature.com
We compared the ability of short hairpin RNA (shRNA) and CRISPR/Cas9 screens to identify
essential genes in the human chronic myelogenous leukemia cell line K562. We found that …
essential genes in the human chronic myelogenous leukemia cell line K562. We found that …
[HTML][HTML] Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function,
but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely …
but can be confounded by nuclease-induced toxicity at both on- and off-target sites, likely …
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
…, J Sun, T Iram, L Bonanno, L Li, DP Lee, DW Morgens… - Nature, 2019 - nature.com
Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …
of protein aggregates and cellular debris. This function deteriorates during ageing and …
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-…
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-…
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
RM Deans, DW Morgens, A Ökesli, S Pillay… - Nature chemical …, 2016 - nature.com
Broad-spectrum antiviral drugs targeting host processes could potentially treat a wide range
of viruses while reducing the likelihood of emergent resistance. Despite great promise as …
of viruses while reducing the likelihood of emergent resistance. Despite great promise as …
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
MS Haney, CJ Bohlen, DW Morgens, JA Ousey… - Nature …, 2018 - nature.com
Phagocytosis is required for a broad range of physiological functions, from pathogen defense
to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates …
to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates …
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen …
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen …