METLIN originated as a database to characterize known metabolites and has since expanded
into a technology platform for the identification of known and unknown metabolites and …

Small molecules are powerful tools for investigating protein function and can serve as leads
for new therapeutics. Most human proteins, however, lack small-molecule ligands, and …

Stimulator of interferon genes (STING) links innate immunity to biological processes ranging
from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the …

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad
discussion on the current state and future directions of the generation and use of peptide …

Sialic acids are a family of structurally related sugars that are prevalent in mucosal surfaces,
including the human intestine. In the gut, sialic acids have diverse biological roles at the …

Macrocyclization is a broadly applied approach for overcoming the intrinsically disordered
nature of linear peptides. Herein, it is shown that dichloroacetone (DCA) enhances helical …

Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly
regulated. We report the identification and characterization of the first small molecules that …

There is significant interest in identifying and characterizing allosteric sites in enzymes such
as protein kinases both for understanding allosteric mechanisms as well as for drug …

Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry.
We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …

Diversity Oriented Clicking (DOC) is a unified click‐approach for the modular synthesis of
lead‐like structures through application of the wide family of click transformations. DOC …