User profiles for D. Bartel
 | David BartelProfessor of Biology, HHMI, MIT, Whitehead Institute Verified email at wi.mit.edu Cited by 240526 |
[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function
DP Bartel - cell, 2004 - cell.com
MicroRNAs (miRNAs) are endogenous ∼22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression. …
roles in animals and plants by targeting mRNAs for cleavage or translational repression. …
[HTML][HTML] MicroRNAs: target recognition and regulatory functions
DP Bartel - cell, 2009 - cell.com
MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their …
MicroRNAs and their regulatory roles in plants
MicroRNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in plants
and animals. In plants, these ∼21-nucleotide RNAs are processed from stem-loop regions …
and animals. In plants, these ∼21-nucleotide RNAs are processed from stem-loop regions …
[HTML][HTML] Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
BP Lewis, CB Burge, DP Bartel - cell, 2005 - cell.com
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with
conserved complementarity to the seed (nucleotides 2–7) of the miRNA. An …
conserved complementarity to the seed (nucleotides 2–7) of the miRNA. An …
The impact of microRNAs on protein output
MicroRNAs are endogenous ∼23-nucleotide RNAs that can pair to sites in the messenger
RNAs of protein-coding genes to downregulate the expression from these messages. …
RNAs of protein-coding genes to downregulate the expression from these messages. …
Phylogenomics resolves the timing and pattern of insect evolution
Insects are the most speciose group of animals, but the phylogenetic relationships of many
major lineages remain unresolved. We inferred the phylogeny of insects from 1478 protein-…
major lineages remain unresolved. We inferred the phylogeny of insects from 1478 protein-…
[HTML][HTML] RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
Double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA through
a process known as RNA interference (RNAi). Using a recently developed Drosophila in …
a process known as RNA interference (RNAi). Using a recently developed Drosophila in …
A uniform system for microRNA annotation
… Similarly, D is a stronger criterion for a hairpin precursor than is C, because D incorporates
phylogenetic conservation to support the precursor structural prediction. Therefore, criterion …
phylogenetic conservation to support the precursor structural prediction. Therefore, criterion …
Most mammalian mRNAs are conserved targets of microRNAs
… We thank members of the Bartel and Burge laboratories for helpful discussions, and the
Broad Institute of MIT and Harvard, the Human Genome Sequencing Center at the Baylor …
Broad Institute of MIT and Harvard, the Human Genome Sequencing Center at the Baylor …
[HTML][HTML] Prediction of mammalian microRNA targets
BP Lewis, I Shih, MW Jones-Rhoades, DP Bartel… - Cell, 2003 - cell.com
MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and
plants by basepairing to mRNAs to specify posttranscriptional repression of these messages. …
plants by basepairing to mRNAs to specify posttranscriptional repression of these messages. …