Objectives Rising demand for emergency and urgent care services is well documented, as
are the consequences, for example, emergency department ( ED ) crowding, increased costs, …

Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Despite the large body of research that examines the determinants of salesperson performance,
significant variation exists regarding how scholars can operationalize salesperson …

Introduction Childhood obesity is one of the most serious global public health challenges.
However, obesity and its consequences are largely preventable. As parents play an important …

Background Exome sequencing is emerging as a first-line diagnostic method in some clinical
disciplines, but its usefulness has yet to be examined for most constitutional disorders in …

Accurate prediction of the functional effect of genetic variation is critical for clinical genome
interpretation. We systematically characterized the transcriptome effects of protein-truncating …

Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …

A class of liberal arts upperclassmen was asked recently to submit estimates of the average
vocabulary of six-year-old children. The guesses ranged from 200 to 20,000! Popular …

… Danny Bradbury explores some of the vulnerabilities surrounding this alternative to
conventional fiat currency, and describes some of the changes being made to ensure it remains …