Analysis of shared heritability in common disorders of the brain

…, D Boomsma, N Eriksson, J Olesen, DI Chasman… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Biological, clinical and population relevance of 95 loci for blood lipids

…, M Koseki, JP Pirruccello, S Ripatti, DI Chasman… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Cumulative psychological stress and cardiovascular disease risk in middle aged and older women: Rationale, design, and baseline characteristics

…, AM Zaslavsky, JE Buring, T Silva, D Chasman… - American heart …, 2017 - Elsevier
Although a growing body of evidence indicates strong links between psychological stress (stress)
and untoward cardiovascular disease (CVD) outcomes, comprehensive examination …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, CC White, F Wiklund, C Barlassina, DI Chasman… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, T Aspelund, T Bhangale, G Boucher, DI Chasman… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

…, BE Cade, JF Casella, B Chalazan, DI Chasman… - Nature, 2021 - nature.com
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

…, S Raychaudhuri, JA Cauley, DI Chasman… - Nature …, 2012 - nature.com
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

…, AS Butterworth, C Carrera, CL Carty, DI Chasman… - Nature …, 2018 - nature.com
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

[HTML][HTML] Genetic risk, adherence to a healthy lifestyle, and coronary disease

…, AG Bick, NR Cook, DI Chasman… - … England Journal of …, 2016 - Mass Medical Soc
Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

…, NJ Timpson, RM Watanabe, R Welch, DI Chasman… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …