Analysis of shared heritability in common disorders of the brain
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
Biological, clinical and population relevance of 95 loci for blood lipids
…, M Koseki, JP Pirruccello, S Ripatti, DI Chasman… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
Cumulative psychological stress and cardiovascular disease risk in middle aged and older women: Rationale, design, and baseline characteristics
…, AM Zaslavsky, JE Buring, T Silva, D Chasman… - American heart …, 2017 - Elsevier
Although a growing body of evidence indicates strong links between psychological stress (stress)
and untoward cardiovascular disease (CVD) outcomes, comprehensive examination …
and untoward cardiovascular disease (CVD) outcomes, comprehensive examination …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, CC White, F Wiklund, C Barlassina, DI Chasman… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, T Aspelund, T Bhangale, G Boucher, DI Chasman… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
…, BE Cade, JF Casella, B Chalazan, DI Chasman… - Nature, 2021 - nature.com
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
…, S Raychaudhuri, JA Cauley, DI Chasman… - Nature …, 2012 - nature.com
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
…, AS Butterworth, C Carrera, CL Carty, DI Chasman… - Nature …, 2018 - nature.com
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
[HTML][HTML] Genetic risk, adherence to a healthy lifestyle, and coronary disease
…, AG Bick, NR Cook, DI Chasman… - … England Journal of …, 2016 - Mass Medical Soc
Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is …
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is …
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
…, NJ Timpson, RM Watanabe, R Welch, DI Chasman… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …