Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …

This review examines the general cellular and molecular underpinnings of human
papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell …

The process of transcript elongation by RNA polymerase II (Pol II) involves transcription-dependent
exchange and displacement of all core histones and is tightly controlled by …

Nucleosomes uniquely positioned on high-affinity DNA sequences present a polar barrier to
transcription by human and yeast RNA polymerase II (Pol II). In one transcriptional …

NOTCH1 mutations have been reported to occur in 10% to 15% of head and neck squamous
cell carcinomas (HNSCC). To determine the significance of these mutations, we embarked …

… In summary, the P- and D-dimers have different roles within the same nucleosome. As
expected, removal of the P-dimer results in a strong Pol II arrest in the +45 region, most likely …

In eukaryotic genomes, nucleosomes function to compact DNA and to regulate access to it
both by simple physical occlusion and by providing the substrate for numerous covalent …

The dominant paradigm for HPV carcinogenesis includes integration into the host genome
followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic …

Development of head and neck squamous cell carcinoma (HNSCC) is characterized by
accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly …

… d Significance of DNA methylation increase in tumor. The red line represents the observed
AUC ratio (tumor/normal) at TSS ± 500 bp region. Gray bars represent the null distribution as …