From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
… from vector production indeed indicate that particle titers from helper plasmids expressing
AAV-5 capsid proteins are higher than those from helpers based on other serotypes [Grimm et …
AAV-5 capsid proteins are higher than those from helpers based on other serotypes [Grimm et …
Current challenges and best-practice protocols for microbiome analysis
Analyzing the microbiome of diverse species and environments using next-generation
sequencing techniques has significantly enhanced our understanding on metabolic, physiological …
sequencing techniques has significantly enhanced our understanding on metabolic, physiological …
[HTML][HTML] Mushroom cultivation in the circular economy
D Grimm, HAB Wösten - Applied microbiology and biotechnology, 2018 - Springer
Commercial mushrooms are produced on lignocellulose such as straw, saw dust, and wood
chips. As such, mushroom-forming fungi convert low-quality waste streams into high-quality …
chips. As such, mushroom-forming fungi convert low-quality waste streams into high-quality …
[PDF][PDF] Loss of epigenetic information as a cause of mammalian aging
…, L Zhong, H Wakimoto, J El Andari, D Grimm… - Cell, 2023 - cell.com
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
D Grimm, KL Streetz, CL Jopling, TA Storm, K Pandey… - Nature, 2006 - nature.com
… d, Continuous treatment with carbon tetrachloride to induce liver damage (demonstrated by
elevated alanine aminotransferase (573–786 IU l -1 ), icteric sera and abnormal morphology …
elevated alanine aminotransferase (573–786 IU l -1 ), icteric sera and abnormal morphology …
[PDF][PDF] 1,135 genomes reveal the global pattern of polymorphism in Arabidopsis thaliana
… d This collection will connect genotypes and phenotypes on a species-wide level … (D) Genetic
distance increases globally with geographic distance for relicts but for non-relicts only over …
distance increases globally with geographic distance for relicts but for non-relicts only over …
ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
…, DC Ferguson, NS Ghoreishi-Haack, DR Grimm… - Clinical cancer …, 2007 - AACR
… PARP inhibition dramatically increased the efficacy of temozolomide at ABT-888 doses as
low as 3.1 mg/kg/d and a maximal efficacy achieved at 25 mg/kg/d. In the 9L orthotopic rat …
low as 3.1 mg/kg/d and a maximal efficacy achieved at 25 mg/kg/d. In the 9L orthotopic rat …
Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada
GR Boyd, H Reemtsma, DA Grimm, S Mitra - Science of the total …, 2003 - Elsevier
… -d 4 and acetaminophen-d 4 ). Fluoxetine was not as stable as our other target analytes;
therefore, fluoxetine standards were prepared from the solid material just prior to use. The …
therefore, fluoxetine standards were prepared from the solid material just prior to use. The …
Novel tools for production and purification of recombinant adenoassociated virus vectors
D Grimm, A Kern, K Rittner, JA Kleinschmidt - Human gene therapy, 1998 - liebertpub.com
Standard protocols for the generation of adenoassociated virus type 2 (AAV-2)-based vectors
for human gene therapy applications require cotransfection of cells with a recombinant …
for human gene therapy applications require cotransfection of cells with a recombinant …
Single-nucleotide polymorphisms in soybean
…, CP Van Tassell, LK Matukumalli, DR Grimm… - Genetics, 2003 - academic.oup.com
… Tajima’s D values were generally positive although none was significant. D was significant
at P < 0.10 in the 9.7 kbp of random noncoding genomic sequence derived from BAC clones …
at P < 0.10 in the 9.7 kbp of random noncoding genomic sequence derived from BAC clones …