Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease. However, …
vaccines are highly effective at preventing infection and especially severe disease. However, …
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
…, S Adamski, A Hicks, S Korte, DA Oldridge… - Science …, 2021 - science.org
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly limited …
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
… D, direct bisulfite sequencing of the enhancer and promoter regions of CD19 (downstream
of the PAX5-binding site) in the paired samples. A CpG island within the HOXA3 locus was …
of the PAX5-binding site) in the paired samples. A CpG island within the HOXA3 locus was …
[PDF][PDF] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific …
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific …
Microplastics in freshwater systems: a review of the emerging threats, identification of knowledge gaps and prioritisation of research needs
Plastic contamination is an increasing environmental problem in marine systems where it
has spread globally to even the most remote habitats. Plastic pieces in smaller size scales, …
has spread globally to even the most remote habitats. Plastic pieces in smaller size scales, …
[HTML][HTML] CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
…, T Perloff, L Sun, D Mathew, JR Giles, DA Oldridge… - Nature medicine, 2021 - nature.com
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …
[HTML][HTML] Overview of methods for enhancing bone regeneration in distraction osteogenesis: potential roles of biometals
Y Li, Q Pan, J Xu, X He, HA Li, DA Oldridge, G Li… - Journal of orthopaedic …, 2021 - Elsevier
Background Distraction osteogenesis (DO) is a functional tissue engineering approach that
applies gradual mechanical traction on the bone tissues after osteotomy to stimulate bone …
applies gradual mechanical traction on the bone tissues after osteotomy to stimulate bone …
[PDF][PDF] Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been …
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been …
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy,
but a large proportion will experience therapy-resistant relapses. The molecular basis of …
but a large proportion will experience therapy-resistant relapses. The molecular basis of …