User profiles for D. Wegmann

Daniel Wegmann

Professor in Computational Biology, University fo Fribourg, Switzerland
Verified email at unifr.ch
Cited by 6258

Work-related musculoskeletal disorders: the epidemiologic evidence and the debate

L Punnett, DH Wegman - Journal of electromyography and kinesiology, 2004 - Elsevier
The debate about work-relatedness of musculoskeletal disorders (MSDs) reflects both
confusion about epidemiologic principles and gaps in the scientific literature. The physical …

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people

MR Nelson, D Wegmann, MG Ehm, D Kessner… - Science, 2012 - science.org
Rare genetic variants contribute to complex disease risk; however, the abundance of rare
variants in human populations remains unknown. We explored this spectrum of variation by …

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

…, N Babaya, E Liu, D Miao, L Yu, DR Wegmann… - Nature, 2005 - nature.com
… In addition, it has been reported that a CD8 T-cell clone recognized insulin B:15–23 and the
alternative mutation of tyrosine to alanine at B16 results in the failure to bind to the K d class …

[HTML][HTML] Prospects and challenges for the conservation of farm animal genomic resources, 2015-2025

…, M Tixier-Boichard, D Wegmann… - Frontiers in …, 2015 - frontiersin.org
Livestock conservation practice is changing rapidly in light of policy developments, climate
change and diversifying market demands. The last decade has seen a step change in …

Prevalence rates and odds ratios of shoulder-neck diseases in different occupational groups.

M Hagberg, DH Wegman - Occupational and environmental medicine, 1987 - oem.bmj.com
The aim of the present study was to evaluate the association and impact of occupational
exposure and diseases of the shoulder and neck. Prevalence rates, odds ratios, aetiological …

Early farmers from across Europe directly descended from Neolithic Aegeans

…, KR Veeramah, D Wegmann… - Proceedings of the …, 2016 - National Acad Sciences
Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes. …

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

…, RG Gill, N Schloot, D Wegmann - European journal of …, 1995 - Wiley Online Library
T cells are known to play an important role in beta cell destruction in the nonobese diabetic (NOD)
mouse model of Type I diabetes and islet‐specific T cell clones have been …

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

D Daniel, DR Wegmann - Proceedings of the National …, 1996 - National Acad Sciences
The observation that overt type I diabetes is often preceded by the appearance of insulin
autoantibodies and the reports that prophylactic administration of insulin to biobreeding …

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

EA Stahl, D Wegmann, G Trynka, J Gutierrez-Achury… - Nature …, 2012 - nature.com
The genetic architectures of common, complex diseases are largely uncharacterized. We
modeled the genetic architecture underlying genome-wide association study (GWAS) data for …

[HTML][HTML] ABCtoolbox: a versatile toolkit for approximate Bayesian computations

D Wegmann, C Leuenberger, S Neuenschwander… - BMC …, 2010 - Springer
… Consider a model creating data D determined by parameters θ whose joint prior density is
… is given by Bayes theorem as π (θ|D)~f(D|θ)π (θ), where f(D|θ) is the likelihood of the data. …