… Houseman, EA et al. DNA methylation arrays as surrogate measures of cell mixture
distribution. BMC Bioinformatics 13, 86 (2012).… E Andres Houseman … E Andres Houseman …

The promise of epigenome-wide association studies and cancer-specific somatic DNA
methylation changes in improving our understanding of cancer, coupled with the decreasing cost …

Due to its convenience, the blood is commonly used in epigenomic studies, but its heterogeneous
nature leads to interpretation difficulties, given the now widely recognized potential for …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Epigenetic control of gene transcription is critical for normal human development and cellular
differentiation. While alterations of epigenetic marks such as DNA methylation have been …

Motivation: Recently there has been increasing interest in the effects of cell mixture on the
measurement of DNA methylation, specifically the extent to which small perturbations in cell …

Background: Head and neck squamous cell carcinoma (HNSCC) is commonly associated
with tobacco and alcohol exposures, although dietary factors, particularly folate, and human …

… between CpG methylation data and patient and tumor covariates, a modified model-based
form of unsupervised clustering known as RPMM was used as described in Houseman et al. ( …

… by using a two-stage regression analysis (eg the Houseman approach [27]) or else fitting a
high-… For example, the Houseman method posits the model Y = AX T + R, where X is an n × d …

… projection (CP) approach for predicting cell-type proportions based on DNA methylation
signatures from a heterogeneous mixture of cells has been described previously by Houseman …