The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of key …

The historical impression that tuberculosis was an inherited disorder has come full circle
and substantial evidence now exists of the human genetic contribution to susceptibility to …

Differentiation of members of the Mycobacterium tuberculosis complex by conventional
mycobacteriological methods is time consuming, making surveillance of species-specific disease …

… EG Hoal was the principal investigator and contributed to study design, analysed and
interpreted the data, and wrote the final manuscript. All investigators contributed to the final version …

Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South …

Background Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of
the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the …

… The plot shows spurious deviations in average local ancestry (eg regions in which the
modelled ancestral population is unusually different from the true ancestral population due to the …

Approximately 20% of persons living in areas hyperendemic for tuberculosis (TB) display
persistent lack of tuberculin skin test (TST) reactivity and appear to be naturally resistant to …

… Because haplotype differentiation between populations can be a signature of selection (eg,
XP-EHH scans), we assessed genetic divergence between KhoeSan, West African, and …