To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …

… Detailed investigation of the contribution of oligogenicity to genotype-phenotype variability
mandates the study of large kindreds with a spectrum of genotypes, eg, F10 (Figure 5). In this …

Genetic defects that affect intestinal epithelial barrier function can present with very early-onset
inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel …

Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital
hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in …

Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype
associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-…

… This may reflect variable compensation by other thyroidal H 2 O 2 -producing enzymes (eg,
DUOX1), influence of other genetic variants affecting thyroid hormone biosynthesis, or …

The objective of this study was to build and develop anaerobic biodigesters for optimization
of biogas production using food waste (FW) and sewage (S) co-digestion from a wastewater …

Dear Editors: In some patients with extreme phenotypes of inflammatory bowel disease (IBD;
in particular in those with infantile or very early onset IBD with< 6 years of onset, …

This article analyzes the case of a Brazilian Institute of Higher Education, in relation to
compliance with a normative instruction, according to which all federal public buildings must …

Organic cultivation of the medicinal species Passiflora incarnata L. is generally a
requirement of the herbal industries. However, there is little information about the nutritional …