The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling
networks. Studies performed in Drosophila over the last 30 years have contributed to our …

The Wnt/β‐catenin signaling pathway plays essential roles during development and adult
tissue homeostasis. Inappropriate activation of the pathway can result in a variety of …

The Wnt pathway has emerged as a key signaling cascade participating in mammary
organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge …

The chickadee gene of Drosophila encodes profilin, a small actin binding protein. We
present the first analysis of the effects of profilin deletion in a multicellular organism. Genomic …

The Wnt/Wingless (Wg) pathway represents a conserved signaling cascade involved in
diverse biological processes. Misregulation of Wnt/Wg signal transduction has profound effects …

Six years ago, DMM launched a subject collection called ‘ Drosophila as a Disease Model ’.
This collection features Review-type articles and original research that highlight the power …

… We are grateful to all Verheyen Lab members who have contributed to Hipk discussions,
in particular Nathan Wray, Kenny Wong, Sharan Swarup, Wendy Lee, Joanna Chen, and …

Homeodomain interacting protein kinase (Hipk) is a member of a novel family of serine/threonine
kinases. Extensive biochemical studies of vertebrate homologs, particularly Hipk2, …

The Hippo (Hpo) tumor suppressor pathway regulates tissue size by inhibiting cell proliferation
and promoting apoptosis [1–5]. The core components of the pathway, Hpo, Salvador, …

At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis.
Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical pathway—which …