User profiles for E. Cuppen

Edwin Cuppen

Hoogleraar Humane Genetica
Verified email at umcutrecht.nl
Cited by 46310

Approaches to microRNA discovery

E Berezikov, E Cuppen, RHA Plasterk - Nature genetics, 2006 - nature.com
MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several
hundred genes encoding miRNAs have been experimentally identified in animals, and many …

Progress and prospects in rat genetics: a community view

TJ Aitman, JK Critser, E Cuppen, A Dominiczak… - Nature …, 2008 - nature.com
The rat is an important system for modeling human disease. Four years ago, the rich 150-year
history of rat research was transformed by the sequencing of the rat genome, ushering in …

Zebrafish as a cancer model

H Feitsma, E Cuppen - Molecular Cancer Research, 2008 - AACR
… Akay, E. Cuppen, unpublished results). B. Cancer growth can be followed in living adult …
Cuppen, unpublished results). B. Cancer growth can be followed in living adult zebrafish. …

Long‐term expanding human airway organoids for disease modeling

…, CHM van Moorsel, CK van der Ent, E Cuppen… - The EMBO …, 2019 - embopress.org
Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential
aspects of organ structure and function. Here, we describe a method to establish long‐term…

[HTML][HTML] Pan-cancer whole-genome analyses of metastatic solid tumours

…, PO Witteveen, EF Smit, S Sleijfer, EE Voest, E Cuppen - Nature, 2019 - nature.com
Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

[HTML][HTML] Long-term culture of genome-stable bipotent stem cells from adult human liver

…, S Strom, RRG Vries, LJW van der Laan, E Cuppen… - Cell, 2015 - cell.com
Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have shown …

[PDF][PDF] A living biobank of breast cancer organoids captures disease heterogeneity

…, PJ van Diest, S Rottenberg, RGJ Vries, E Cuppen… - Cell, 2018 - cell.com
Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically,
and clinically. Here, we describe a robust protocol for long-term culturing of human …

[PDF][PDF] Organoid models of human and mouse ductal pancreatic cancer

…, FHM Morsink, IQ Molenaar, IHB Rinkes, E Cuppen… - Cell, 2015 - cell.com
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …

[PDF][PDF] Mammalian mirtron genes

E Berezikov, WJ Chung, J Willis, E Cuppen, EC Lai - Molecular cell, 2007 - cell.com
Mirtrons are alternative precursors for microRNA biogenesis that were recently described in
invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is …

[HTML][HTML] Phylogenetic shadowing and computational identification of human microRNA genes

…, J van de Belt, E Wienholds, RHA Plasterk, E Cuppen - Cell, 2005 - cell.com
We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …