User profiles for E. Cuppen
Edwin CuppenHoogleraar Humane Genetica Verified email at umcutrecht.nl Cited by 46310 |
Approaches to microRNA discovery
MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several
hundred genes encoding miRNAs have been experimentally identified in animals, and many …
hundred genes encoding miRNAs have been experimentally identified in animals, and many …
Progress and prospects in rat genetics: a community view
TJ Aitman, JK Critser, E Cuppen, A Dominiczak… - Nature …, 2008 - nature.com
The rat is an important system for modeling human disease. Four years ago, the rich 150-year
history of rat research was transformed by the sequencing of the rat genome, ushering in …
history of rat research was transformed by the sequencing of the rat genome, ushering in …
Zebrafish as a cancer model
H Feitsma, E Cuppen - Molecular Cancer Research, 2008 - AACR
… Akay, E. Cuppen, unpublished results). B. Cancer growth can be followed in living adult …
Cuppen, unpublished results). B. Cancer growth can be followed in living adult zebrafish. …
Cuppen, unpublished results). B. Cancer growth can be followed in living adult zebrafish. …
Long‐term expanding human airway organoids for disease modeling
…, CHM van Moorsel, CK van der Ent, E Cuppen… - The EMBO …, 2019 - embopress.org
Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential
aspects of organ structure and function. Here, we describe a method to establish long‐term…
aspects of organ structure and function. Here, we describe a method to establish long‐term…
[HTML][HTML] Pan-cancer whole-genome analyses of metastatic solid tumours
Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …
better understanding of the characteristics of late-stage cancer is required to help adapt …
[HTML][HTML] Long-term culture of genome-stable bipotent stem cells from adult human liver
Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have shown …
systems available that sustain hepatocyte replication and/or function in vitro. We have shown …
[PDF][PDF] A living biobank of breast cancer organoids captures disease heterogeneity
…, PJ van Diest, S Rottenberg, RGJ Vries, E Cuppen… - Cell, 2018 - cell.com
Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically,
and clinically. Here, we describe a robust protocol for long-term culturing of human …
and clinically. Here, we describe a robust protocol for long-term culturing of human …
[PDF][PDF] Organoid models of human and mouse ductal pancreatic cancer
…, FHM Morsink, IQ Molenaar, IHB Rinkes, E Cuppen… - Cell, 2015 - cell.com
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …
response to treatment. Tractable methods to identify and interrogate pathways involved in …
[PDF][PDF] Mammalian mirtron genes
Mirtrons are alternative precursors for microRNA biogenesis that were recently described in
invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is …
invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is …
[HTML][HTML] Phylogenetic shadowing and computational identification of human microRNA genes
We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …