Systems pharmacology aims to holistically understand mechanisms of drug actions to support
drug discovery and clinical practice. Systems pharmacology modeling (SPM) is data driven…

Coevolutionary sequence analysis has become a commonly used technique for de novo
prediction of the structure and function of proteins, RNA, and protein complexes. We present …

… In addition to that the query sequence is compared using BLAST against all curated
sequences in the HistoneDB 2.0 and the list of similar sequences sorted by BLAST E-values are …

In September 2015, member states of the United Nations unanimously adopted the
Sustainable Development Goals (SDGs)—a set of 17 ambitions for the post-2015 global …

… However, in most cases the dictionary will not provide a pathway from the E-isomer to the
Z-isomer, as each is a local minimum. To restrain the molecule to a specific cis–trans isomer, a …

Highlights • Data science has emerged as a fourth paradigm of science, alongside the
theoretical, experimental, and computational. • Structural biology’s rich history has emphasized …

Background Machine learning (ML) has a rich history in structural bioinformatics, and
modern approaches, such as deep learning, are revolutionizing our knowledge of the subtle …

The purpose of this study was to update a 1976 study by Arthur D. Little, Inc., on the use of
automatic ECG analysis systems. Thirteen vendors of computerized ECG systems received …

… Usein connectionwith anyform ofinformation storage and retrieval, electronic adaptation,
computer software, or by similar or dissimilar methodologynow known orhereafter developed is …

Our views of fold space implicitly rest upon many assumptions that impact how we analyze,
interpret and understand biological systems—from protein structure comparison and …