User profiles for E. Eitan
 | Erez EitanNational Institute on Aging Verified email at neurodex.co Cited by 3945 |
Impact of lysosome status on extracellular vesicle content and release
Extracellular vesicles (EVs) are nanoscale size bubble-like membranous structures released
from cells. EVs contain RNA, lipids and proteins and are thought to serve various roles …
from cells. EVs contain RNA, lipids and proteins and are thought to serve various roles …
Telomere shortening in neurological disorders: an abundance of unanswered questions
Telomeres, ribonucleoprotein complexes that cap eukaryotic chromosomes, typically shorten
in leukocytes with aging. Aging is a primary risk factor for neurodegenerative disease (ND), …
in leukocytes with aging. Aging is a primary risk factor for neurodegenerative disease (ND), …
Are there roles for brain cell senescence in aging and neurodegenerative disorders?
The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …
Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case‐control study
Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally
derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. …
derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. …
[HTML][HTML] Plasma extracellular vesicles enriched for neuronal origin: a potential window into brain pathologic processes
M Mustapic, E Eitan, JK Werner Jr… - Frontiers in …, 2017 - frontiersin.org
Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for
neuronal origin from peripheral blood and using them as a biomarker discovery platform for …
neuronal origin from peripheral blood and using them as a biomarker discovery platform for …
[HTML][HTML] Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease
… Kapogiannis selected and evaluated the patients with AD and edited the manuscript; E.
Eitan cultured rat neural cells; IV Lobach conducted all statistical analyses; L. Goetzl designed …
Eitan cultured rat neural cells; IV Lobach conducted all statistical analyses; L. Goetzl designed …
Altered extracellular vesicle concentration, cargo, and function in diabetes
Type 2 diabetes is a chronic age-associated degenerative metabolic disease that reflects
relative insulin deficiency and resistance. Extracellular vesicles (EVs) (exosomes, …
relative insulin deficiency and resistance. Extracellular vesicles (EVs) (exosomes, …
[HTML][HTML] Age-related changes in plasma extracellular vesicle characteristics and internalization by leukocytes
… PKH26 labeled EVs were then added to PBMCs in the doses between 2.00 E+08 –5.75 E+09
particles. The PBMCs and EVs were then incubated for 1–24 hours in RPMI complete …
particles. The PBMCs and EVs were then incubated for 1–24 hours in RPMI complete …
Association of extracellular vesicle biomarkers with Alzheimer disease in the Baltimore longitudinal study of aging
…, S Chawla, S Gulyani, E Eitan… - JAMA …, 2019 - jamanetwork.com
… Conflict of Interest Disclosures: Dr Eitan reports personal fees from NeuroDex outside the
submitted work. Drs Lyketsos and Oh were supported by the Johns Hopkins Alzheimer …
submitted work. Drs Lyketsos and Oh were supported by the Johns Hopkins Alzheimer …
Extracellular vesicle–depleted fetal bovine and human sera have reduced capacity to support cell growth
… -depleted FBS: i s o l a t e d E V s / m l ( F B S ) ( p a r t i c i e s i n 1 m l F B S ) - ( p a r t i c i
e s i n 1 E V d e p l e t e d F B S ) . The efficiency of EV removal was size dependent ( Fig. 1 F). …
e s i n 1 E V d e p l e t e d F B S ) . The efficiency of EV removal was size dependent ( Fig. 1 F). …