User profiles for E. Marcotte

Edward Marcotte

Professor of Molecular Biosciences, University of Texas at Austin
Verified email at utexas.edu
Cited by 44786

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

C Vogel, EM Marcotte - Nature reviews genetics, 2012 - nature.com
Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented
ability to survey mRNA and protein abundances. Such proteome-wide surveys are …

Global signatures of protein and mRNA expression levels

R de Sousa Abreu, LO Penalva, EM Marcotte… - Molecular …, 2009 - pubs.rsc.org
Cellular states are determined by differential expression of the cell’s proteins. The relationship
between protein and mRNA expression levels informs about the combined outcomes of …

Protein function in the post-genomic era

D Eisenberg, EM Marcotte, I Xenarios, TO Yeates - Nature, 2000 - nature.com
Faced with the avalanche of genomic sequences and data on messenger RNA expression,
biological scientists are confronting a frightening prospect: piles of information but only flakes …

[HTML][HTML] The genome sequence of the filamentous fungus Neurospora crassa

…, GO Kothe, G Jedd, W Mewes, C Staben, E Marcotte… - Nature, 2003 - nature.com
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry
and molecular biology. Here, we report a high-quality draft sequence of the N. crassa …

Assigning protein functions by comparative genome analysis: protein phylogenetic profiles

M Pellegrini, EM Marcotte… - Proceedings of the …, 1999 - National Acad Sciences
… We find that more than half of the E. coli proteins with the RL7 phylogenetic profile or
profiles that differ from it by one bit have functions associated with the ribosome (Fig. 2A). …

Detecting protein function and protein-protein interactions from genome sequences

EM Marcotte, M Pellegrini, HL Ng, DW Rice, TO Yeates… - Science, 1999 - science.org
… to predict that Gyr A and Gyr B interact in E. coli. To find other such putative protein interactions
in E. coli, we searched the 4290 protein sequences of the E. coli genome (4) for these …

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation

P Lu, C Vogel, R Wang, X Yao, EM Marcotte - Nature biotechnology, 2007 - nature.com
… the variance in yeast protein abundance (47% in E. coli) is explained by mRNA abundance,
… We apply APEX to characterize the yeast and E. coli proteomes and their transcriptional and …

DIP: the database of interacting proteins

…, L Salwinski, MK Baron, EM Marcotte… - Nucleic acids …, 2000 - academic.oup.com
The Database of Interacting Proteins (DIP; http://dip.doe-mbi.ucla.edu ) is a database that
documents experimentally determined protein–protein interactions. This database is intended …

A combined algorithm for genome-wide prediction of protein function

EM Marcotte, M Pellegrini, MJ Thompson, TO Yeates… - Nature, 1999 - nature.com
The availability of over 20 fully sequenced genomes has driven the development of new
methods to find protein function and interactions. Here we group proteins by correlated …

[HTML][HTML] A census of human soluble protein complexes

…, SJ Wodak, ERM Tillier, A Paccanaro, EM Marcotte… - Cell, 2012 - cell.com
Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited. …