User profiles for F. P. Barthel
Floris P BarthelThe Translational Genomics Research Institute (TGen) Verified email at tgen.org Cited by 6921 |
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future …
…, BM Alexander, JS Barnholtz-Sloan, FP Barthel… - Neuro …, 2020 - academic.oup.com
Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …
cause of morbidity and mortality. In recent years there have been important advances in …
[PDF][PDF] Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …
glioma driving alterations and suboptimal disease classification. We defined the complete …
[HTML][HTML] Reconstructing the molecular life history of gliomas
FP Barthel, P Wesseling, RGW Verhaak - Acta neuropathologica, 2018 - Springer
At the time of their clinical manifestation, the heterogeneous group of adult and pediatric
gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic …
gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic …
Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 …
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 …
[PDF][PDF] Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
Longitudinal molecular trajectories of diffuse glioma in adults
The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …
understanding of its genomic impact is limited. We analyzed mutational spectra following …
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
…, KJ Anderson, ET Courtois, AD Gujar, FP Barthel… - Nature …, 2021 - nature.com
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments
and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, …
and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, …
[PDF][PDF] Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
…, L Baker, M Balasundaram, S Balu, FP Barthel… - Cell, 2017 - cell.com
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …