Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …

The obesity epidemic is responsible for a substantial economic burden in developed countries
and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is …

Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline
study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

We screened variants on an exome-focused genotyping array in> 300,000 participants (replication
in> 280,000 participants) and identified 444 independent variants in 250 loci …

… can act as a trans regulator of hemoglobin F levels (21), whereas expression of HBS1L (a
putative member of the GTPase superfamily) correlates with high F cell alleles (6). In addition …

Background Genomewide association studies of autoimmune diseases have mapped hundreds
of susceptibility regions in the genome. However, only for a few association signals has …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on "self" result in …

Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …