Objective The risk-benefit profile of antidepressant medications in bipolar disorder is
controversial. When conclusive evidence is lacking, expert consensus can guide treatment …

… We recommend utilizing the definition proposed by Colom et al. (71) for predominant
polarity, ie, at least two-thirds of lifetime episodes being of one polarity or the other (PD or PM). …

… In addition, authors were unable to find any overall prophylactic efficacy with patients having
had more than 15 episodes [Colom F, Unpublished Data]. In summary, early- versus late-…

OBJECTIVE: The study aims were to address neuropsychological functioning across
different states of bipolar illness and to determine relationships among clinical features, …

Objective: Cognitive impairment in bipolar disorder may be a stable characteristic of the
illness, although discrepancies have emerged with regard to what dysfunctions remain during …

Background Numerous studies have documented high rates of functional impairment among
bipolar disorder (BD) patients, even during phases of remission. However, the majority of …

Background Studies on individual psychotherapy indicate that some interventions may
reduce the number of recurrences in bipolar patients. However, there has been a lack of …

BackgroundThe long-term efficacy of psychological interventions for bipolar disorders has
not been tested.AimsThis study assessed the efficacy of group psychoeducation to prevent …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Background: Noncompliance with medication is a very common feature among bipolar
patients. Rates of poor compliance may reach 64% for bipolar disorders, and noncompliance is …