Through cultural innovation and changes in habitat and ecology, there have been a number
of major dietary shifts in human evolution, including meat eating, cooking, and those …

The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis.
Previous work with cell-free systems has revealed four components required for cyclin-…

In the clam, Spisula, two previously described proteins known as cyclin A and B display the
unusual property of selective proteolytic degradation at the end of each mitosis. We show …

Aims Despite its proven efficacy, the Cox-Maze III procedure did not gain widespread acceptance
for the treatment of stand-alone atrial fibrillation (SA-AF) because of its complexity and …

Background Elevated proinflammatory cytokines are associated with greater COVID-19 severity.
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …

Individuals from different populations vary considerably in their susceptibility to immune-related
diseases. To understand how genetic variation and natural selection contribute to these …

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people, …

The spindle assembly checkpoint keeps cells with defective spindles from initiating chromosome
segregation. The protein kinase Mps1 phosphorylates the yeast protein Mad1p when …

Information System (IS) development has been beset by consistency problems since its
infancy. These problems are greater still in UML software development, and are principally …

Background: The use of ketoconazole has been recently questioned after warnings from the
European Medicine Agencies and the Food and Drug Administration due to potential …