User profiles for F. Pardo Manuel de Villena
 | Fernando Pardo-Manuel de VillenaProfessor and Chair, Department of Genetics, University of North Carolina Chapel Hill Verified email at med.unc.edu Cited by 12308 |
Nonrandom segregation during meiosis: the unfairness of females
F Pardo-Manuel De Villena, C Sapienza - Mammalian Genome, 2001 - Springer
… occurs (PardoManuel de Villena et al. 2000a). Another difference between the two types
of drive systems concerns the linkage relationship between Responders and Distorters. …
of drive systems concerns the linkage relationship between Responders and Distorters. …
On the subspecific origin of the laboratory mouse
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct
subspecific origins. We have developed a high-resolution map of the origin of the laboratory …
subspecific origins. We have developed a high-resolution map of the origin of the laboratory …
[HTML][HTML] The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems …
Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome
substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources …
substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources …
The collaborative cross: a recombinant inbred mouse population for the systems genetic era
The mouse is the most extensively used mammalian model for biomedical and aging
research, and an extensive catalogue of laboratory resources is available to support research …
research, and an extensive catalogue of laboratory resources is available to support research …
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …
that are not fully understood. Because regulatory elements are conserved between humans …
The mouse universal genotyping array: from substrains to subspecies
…, L McMillan, F Pardo-Manuel de Villena - G3: Genes …, 2016 - academic.oup.com
Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
[HTML][HTML] Modeling host genetic regulation of influenza pathogenesis in the collaborative cross
…, MG Katze, F Pardo-Manuel de Villena… - PLoS …, 2013 - journals.plos.org
Genetic variation contributes to host responses and outcomes following infection by
influenza A virus or other viral infections. Yet narrow windows of disease symptoms and …
influenza A virus or other viral infections. Yet narrow windows of disease symptoms and …
C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response
… Parental strains, F 1 , and F 2 animals were tested concurrently. C57BL/6N had an ~1-SD
lower response to cocaine. The F 1 animals exhibited a cocaine response similar to that of …
lower response to cocaine. The F 1 animals exhibited a cocaine response similar to that of …
[HTML][HTML] Genome wide identification of SARS-CoV susceptibility loci using the collaborative cross
New systems genetics approaches are needed to rapidly identify host genes and genetic
networks that regulate complex disease outcomes. Using genetically diverse animals from …
networks that regulate complex disease outcomes. Using genetically diverse animals from …
[HTML][HTML] Status and access to the Collaborative Cross population
The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight
genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC …
genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC …