… Papoian and Wolynes developed a theory of the coupling between binding and folding
energy landscapes (Papoian & Wolynes, 2003), which can be used to study binding and folding …

… Savelyev and Papoian2 systematically derived a two-bead per … was introduced by Savelyev
and Papoian as a generalization of … The effective Hamiltonian of the Savelyev and Papoian …

Proteins have evolved to use water to help guide folding. A physically motivated,
nonpairwise-additive model of water-mediated interactions added to a protein structure prediction …

The associative memory, water mediated, structure and energy model (AWSEM) is a coarse-grained
protein force field. AWSEM contains physically motivated terms, such as hydrogen …

… at the University of North Carolina at Chapel Hill under Garegin Papoian. His research is …
Papoian was born in Yerevan, Armenia in 1973. He completed 4 years of undergraduate …

… Such an analytical model, based on the energy landscape theory, has recently been put
forward by Papoian and Wolynes. We envision that prior to binding both partner proteins are …

Coarse-grained (CG) modeling approaches are widely used to simulate many important
biological processes involving DNA, including chromatin folding and genomic packaging. The …

Condensation of monovalent counterions around DNA influences polymer properties of the
DNA chain. For example, the Na + ions show markedly stronger propensity to induce …

The nucleosome is the fundamental unit for packaging the genome. A detailed molecular
picture for its conformational dynamics is crucial for understanding transcription and gene …

We investigate protein–protein association using the associative-memory, water-mediated,
structure, and energy model (AWSEM), a coarse-grained protein folding model that has been …