Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

IN Western Europe and the United States approximately 1 in 12 women develop breast cancer.
A small proportion of breast cancer cases, in particular those arising at a young age, are …

Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

… We thank G. Getz and colleagues for the design of this figure 26 . ALL, acute lymphoblastic
leukaemia; AML, acute myeloid leukaemia; CLL, chronic lymphocytic leukaemia. …

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation …

… melanoma metastasized, resulting in a reduced rate of C>T/G>A mutation. Moreover, the
increased proportion of C>A/G>T in the later phase suggests that the process underlying these …

… For example, G>T/C>A transversions predominate in smoking-associated lung cancer, a …
patterns include G>T transversions in aflatoxin B1-associated hepatocellular carcinomas ( …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some
cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here…

… The mutation spectrum of this case was distinctive, featuring C·G → T·A, C·G → G·C and C·G
→ … Specifically, if φ g , ψ g ∈ {1, 2} index whether the gene g does or does not belong to the …

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …