Advances in microscopy and genomic techniques have provided new insight into spatial
chromatin organization inside of the nucleus. In particular, chromosome conformation capture …

We have achieved mobilities in excess of 200,000 cm 2 V −1 s −1 at electron densities of ∼2
×10 11 cm −2 by suspending single layer graphene. Suspension ∼150 nm above a Si/SiO …

… Fudenberg et al. propose that TADs emerge as a consequence of loop extrusion limited by
boundary elements. The authors use polymer simulations and genomic analyses to identify …

Extracting biologically meaningful information from chromosomal interactions obtained with
genome-wide chromosome conformation capture (3C) analyses requires the elimination of …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Recently, Chromosome Conformation Capture (3C) based experiments have highlighted
the importance of computational models for the study of chromosome organization. In this …

… domains, we determined the radius of gyration (R g ), defined as the root-mean square …
Power-law scaling was also observed for R g as a function of L, that is, R g ∝ L c , with the …

Eukaryotic chromatin, is far from being simply a randomly arranged polymer in the cell nucleus.
Rather, Hi-C and imaging reveal a high degree of spatial organization on various length …

The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic
and inactive heterochromatic regions of the genome 1 , 2 . In conventional nuclei, …