User profiles for G. Isom

Georgia Isom

NYU Langone School of Medicine
Verified email at nyulangone.org
Cited by 583

NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implications for cell death

…, AG Kanthasamy, JL Borowitz, GE Isom - Journal of …, 1995 - Wiley Online Library
… X 10' cells/ ml on a 35-mm culture dish containing a sterile coverslip previously coated
with 0.1 g/ml poly-t.-lysine (molecular weight 30,000-70,000) and used for experiments in 9-10 …

Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity

…, L Li, K Prabhakaran, JL Borowitz, GE Isom - Toxicological …, 2008 - academic.oup.com
Acute cyanide toxicity is attributed to inhibition of cytochrome c oxidase (CcOX), the oxygen-reducing
component of mitochondrial electron transport; however, the mitochondrial action …

Excitotoxins, aging, and environmental neurotoxins: implications for understanding human neurodegenerative diseases

…, MF Beal, SC Bondy, DA DiMonte, GE Isom - Toxicology and applied …, 1995 - Elsevier
We are an aging society and current demographic trends point to a likely increase in age-related
neurodegenerative diseases. The aged population may have a number of unique risk …

[PDF][PDF] Architectures of lipid transport systems for the bacterial outer membrane

DC Ekiert, G Bhabha, GL Isom, G Greenan… - Cell, 2017 - cell.com
How phospholipids are trafficked between the bacterial inner and outer membranes through
the hydrophilic space of the periplasm is not known. We report that members of the …

NF‐κB‐mediated up‐regulation of Bcl‐XS and Bax contributes to cytochrome c release in cyanide‐induced apoptosis

…, N Li, L Li, JL Borowitz, GE Isom - Journal of …, 2002 - Wiley Online Library
… at 500 g for 5 min at 4C and the resulting supernatant was centrifuged at 10 000 g for 30
min at 4C to obtain the heavy membrane pellet (HM) enriched for mitochondria. The 10 000 g

Dopamine‐induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells

…, PG Gunasekar, JL Borowitz, GE Isom - Journal of …, 2000 - Wiley Online Library
Dopamine (DA) oxidation and the generation of reactive oxygen species (ROS) may contribute
to the degeneration of dopaminergic neurons underlying various neurological conditions. …

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

…, V Spana, IT Cadby, C Harding, GL Isom… - Nature …, 2019 - nature.com
The Mla pathway is believed to be involved in maintaining the asymmetrical Gram-negative
outer membrane via retrograde phospholipid transport. The pathway is composed of three …

Cyanide-induced neurotoxicity: role of neuronal calcium

JD Johnson, TL Meisenheimer, GE Isom - Toxicology and applied …, 1986 - Elsevier
… KCN (10 mg/kg, sc) significantly increased whole-brain total calcium levels from 48.1 ± 1.8
to 66.5 ± 3.9 μg/g dry wt within 15 min after administration. The levels remained elevated for 3 …

Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication

BK Ardelt, JL Borowitz, GE Isom - Toxicology, 1989 - Elsevier
… The slurry was centrifuged for 10 min at 260 g, the supernatant removed and stored in 12-ml
glass stoppered conical centrifuge tubes purged with N 2. The tissue pellet was …

[PDF][PDF] LetB structure reveals a tunnel for lipid transport across the bacterial envelope

GL Isom, N Coudray, MR MacRae, CT McManus… - Cell, 2020 - cell.com
Gram-negative bacteria are surrounded by an outer membrane composed of phospholipids
and lipopolysaccharide, which acts as a barrier and contributes to antibiotic resistance. The …