Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoter
G Kovacikova, K Skorupski - Molecular microbiology, 2002 - Wiley Online Library
… 7, changing the T at position −85 to a G in the C6706 promoter fragment had no effect on …
Influence of the C6706 G-77T change on virulence gene expression As the G-77T change in …
Influence of the C6706 G-77T change on virulence gene expression As the G-77T change in …
A Vibrio cholerae LysR Homolog, AphB, Cooperates with AphA at the tcpPH Promoter To Activate Expression of the ToxR Virulence Cascade
G Kovacikova, K Skorupski - Journal of bacteriology, 1999 - Am Soc Microbiol
We describe here a new member of the LysR family of transcriptional regulators, AphB, which
is required for activation of the Vibrio cholerae ToxR virulence cascade. AphB activates the …
is required for activation of the Vibrio cholerae ToxR virulence cascade. AphB activates the …
Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP‐CRP at the Vibrio cholerae tcpPH promoter
G Kovacikova, K Skorupski - Molecular microbiology, 2001 - Wiley Online Library
… The A at −65 that is critical for transcriptional activation by AphB lies within the dyad, and
the presence of a G in this position in the El Tor promoter disrupts the symmetry of the site. …
the presence of a G in this position in the El Tor promoter disrupts the symmetry of the site. …
A selective review of glutamate pharmacological therapy in obsessive–compulsive and related disorders
MA Grados, EB Atkins, GI Kovacikova… - … research and behavior …, 2015 - Taylor & Francis
… Citation55 In a placebo-controlled double-blind study of OCD, Citation56 24 subjects
were assigned glycine 60 g/day or placebo. Glycine noncompliance, partly due a lack of …
were assigned glycine 60 g/day or placebo. Glycine noncompliance, partly due a lack of …
Characterization of Vibrio cholerae O1 El Tor biotype variant clinical isolates from Bangladesh and Haiti, including a molecular genetic analysis of virulence genes
… A missense mutation of an A 266 G in the coding region, resulting in an amino acid change
from asparagine to serine (N 89 S), was found in Bgd3, Bgd4, Bgd5, Bgd6, MQ1795, MQ04, …
from asparagine to serine (N 89 S), was found in Bgd3, Bgd4, Bgd5, Bgd6, MQ1795, MQ04, …
The LysR-Type Virulence Activator AphB Regulates the Expression of Genes in Vibrio cholerae in Response to Low pH and Anaerobiosis
G Kovacikova, W Lin, K Skorupski - Journal of bacteriology, 2010 - Am Soc Microbiol
AphB is a LysR-type activator that initiates the expression of the virulence cascade in Vibrio
cholerae by cooperating with the quorum-sensing-regulated activator AphA at the tcpPH …
cholerae by cooperating with the quorum-sensing-regulated activator AphA at the tcpPH …
Dual regulation of genes involved in acetoin biosynthesis and motility/biofilm formation by the virulence activator AphA and the acetate‐responsive LysR‐type …
G Kovacikova, W Lin, K Skorupski - Molecular microbiology, 2005 - Wiley Online Library
… Sequencing of the resulting products revealed that the transcriptional start of alsD is an A
27 bp upstream of its ATG and that of alsR is either an A or a G 33–34 bp upstream of its ATG (…
27 bp upstream of its ATG and that of alsR is either an A or a G 33–34 bp upstream of its ATG (…
The Alternative Sigma Factor σE Plays an Important Role in Intestinal Survival and Virulence in Vibrio cholerae
G Kovacikova, K Skorupski - Infection and immunity, 2002 - Am Soc Microbiol
… Sequencing of the major resulting PCR product revealed a transcriptional start site (G) 93 nt
… of it revealed a second transcriptional start site (G or C) 309 to 310 nt upstream of the ATG …
… of it revealed a second transcriptional start site (G or C) 309 to 310 nt upstream of the ATG …
The quorum sensing regulator HapR downregulates the expression of the virulence gene transcription factor AphA in Vibrio cholerae by antagonizing Lrp‐ and VpsR …
W Lin, G Kovacikova, K Skorupski - Molecular microbiology, 2007 - Wiley Online Library
… naturally occurring G-77T change … Kovacikova and Skorupski, 2002a) because in both of
these strains, HapR is unable to repress the aphA promoter. However, the Δlrp mutation in the G…
these strains, HapR is unable to repress the aphA promoter. However, the Δlrp mutation in the G…
Integration Host Factor Positively Regulates Virulence Gene Expression in Vibrio cholerae
E Stonehouse, G Kovacikova, RK Taylor… - Journal of …, 2008 - Am Soc Microbiol
… Unlike H-NS, IHF recognizes a specific asymmetric site on DNA, the 13-bp consensus
target sequence WATCAANNNNTTR, where W represents A or T and R represents A or G (10). …
target sequence WATCAANNNNTTR, where W represents A or T and R represents A or G (10). …