User profiles for G. Seydoux
 | Geraldine SeydouxJohns Hopkins University Verified email at jhmi.edu Cited by 15305 |
[HTML][HTML] Pathway to totipotency: lessons from germ cells
G Seydoux, RE Braun - Cell, 2006 - cell.com
Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate
all cell types after fertilization. Accumulating evidence suggests that this extraordinary …
all cell types after fertilization. Accumulating evidence suggests that this extraordinary …
RNA granules in germ cells
E Voronina, G Seydoux… - Cold Spring …, 2011 - cshperspectives.cshlp.org
“Germ granules” are cytoplasmic, nonmembrane-bound organelles unique to germline.
Germ granules share components with the P bodies and stress granules of somatic cells, but …
Germ granules share components with the P bodies and stress granules of somatic cells, but …
Regulation of the oocyte-to-zygote transition
ML Stitzel, G Seydoux - Science, 2007 - science.org
Oocytes, the female germ cells, contain all the messenger RNAs necessary to start a new
life but typically wait until fertilization to begin development. The transition from oocyte to …
life but typically wait until fertilization to begin development. The transition from oocyte to …
Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution
… (G) OTFs for the dithered hexagonal lattice used in (C). (H) OTFs for the swept Bessel
mode used in (D). Green curves in (E) to (H) represent the diffraction limit of the detection. …
mode used in (D). Green curves in (E) to (H) represent the diffraction limit of the detection. …
High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
… a sgRNA at the gtbp-1 locus and obtained 20% edits (Table 2, experiment AP92), a frequency
comparable to that of the original sgRNA we used at that locus, which ends in a single G. …
comparable to that of the original sgRNA we used at that locus, which ends in a single G. …
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
10.7554/eLife.04591.001 RNA granules have been likened to liquid droplets whose dynamics
depend on the controlled dissolution and condensation of internal components. The …
depend on the controlled dissolution and condensation of internal components. The …
Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila …
G Seydoux, MA Dunn - Development, 1997 - journals.biologists.com
Early embryonic germ cells in C. elegans and D. melanogaster fail to express many
messenger RNAs expressed in somatic cells. In contrast, we find that ribosomal RNAs are …
messenger RNAs expressed in somatic cells. In contrast, we find that ribosomal RNAs are …
[PDF][PDF] 3′ UTRs are the primary regulators of gene expression in the C. elegans germline
How genes are regulated to produce the correct assortment of proteins for every cell type is
a fundamental question in biology. For many genes, regulation begins at the DNA level with …
a fundamental question in biology. For many genes, regulation begins at the DNA level with …
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
G Seydoux, A Fire - Development, 1994 - journals.biologists.com
Early embryogenesis in Caenorhabditis elegans is characterized by a series of unequal
cleavages that mark the stepwise separation of somatic and germ lineages. We have developed …
cleavages that mark the stepwise separation of somatic and germ lineages. We have developed …
Repression of gene expression in the embryonic germ lineage of C. elegans
THE distinction between soma and germline was recognized more than a century ago:
somatic cells form the body of an organism, whereas germ cells serve to produce future …
somatic cells form the body of an organism, whereas germ cells serve to produce future …