User profiles for H. U. Klein

Hans-Ulrich Klein

Columbia University Medical Center
Verified email at columbia.edu
Cited by 8945

[HTML][HTML] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

…, K Chiba, H Tanaka, HP Koeffler, HU Klein… - Leukemia, 2014 - nature.com
High-throughput DNA sequencing significantly contributed to diagnosis and prognostication
in patients with myelodysplastic syndromes (MDS). We determined the biological and …

Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart …

…, JCC Moon, NG Bellenger, P Collins, HU Klein… - The American journal of …, 2002 - Elsevier
Fast breath-hold cardiovascular magnetic resonance (CMR) shows excellent results for
interstudy reproducibility of left ventricular (LV) volumes, ejection fraction, and mass, which are …

Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation

…, JC Geller, C Huth, S Ansorge, HU Klein… - Journal of the American …, 2000 - jacc.org
OBJECTIVES The purpose of this study was to determine whether atrial expression of the
extracellular signal-regulated kinases Erk1/Erk2 and of the angiotensin-converting enzyme (…

Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance

…, JC Moon, NG Bellenger, GS Smith, HU Klein… - American heart …, 2004 - Elsevier
BACKGROUND: Cardiovascular magnetic resonance (CMR) has shown excellent results
for interstudy reproducibility in the assessment of left ventricular (LV) parameters. However, …

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

…, S Göllner, L Howell, L Jin, K Hebestreit, HU Klein… - Nature medicine, 2012 - nature.com
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid
leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been …

Left ventricular lead position and clinical outcome in the Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT) trial

JP Singh, HU Klein, DT Huang, S Reek, M Kuniss… - Circulation, 2011 - Am Heart Assoc
Background— An important determinant of successful cardiac resynchronization therapy for
heart failure is the position of the left ventricular (LV) pacing lead. The aim of this study was …

Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans

…, T Staack, JC Geller, C Huth, S Ansorge, HU Klein… - Circulation, 2000 - Am Heart Assoc
Background—Previous studies have suggested that atrial fibrillation (AF) is associated with
the activation of the atrial angiotensin system. However, it is not known whether the …

[PDF][PDF] Inherited and somatic defects in DDX41 in myeloid neoplasms

…, JE Churpek, DA Pollyea, U Krug, WE Berdel, HU Klein… - Cancer cell, 2015 - cell.com
Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …

[HTML][HTML] Survival with cardiac-resynchronization therapy in mild heart failure

I Goldenberg, V Kutyifa, HU Klein… - … England Journal of …, 2014 - Mass Medical Soc
Background The Multicenter Automatic Defibrillator Implantation Trial with Cardiac
Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac-…

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

B Ng, CC White, HU Klein, SK Sieberts… - Nature …, 2017 - nature.com
We report a multi-omic resource generated by applying quantitative trait locus (xQTL) analyses
to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral …