International and local surveillance networks as well as numerous reports in the biomedical
literature provide evidence that the prevalence of antibiotic resistant Gram-negative bacteria …

Metallo-β-lactamases are resistance determinants of increasing clinical relevance in Gram-negative
bacteria. Because of their broad range, potent carbapenemase activity and …

Although the rapid spread of carbapenemase-producing Gram-negatives (CPGNs) is
providing the scientific community with a great deal of information about the molecular …

… 0.046 h and 2.3 h, respectively. The clearance of CMS was 13.7 liters/h. For colistin, a
one-compartment model was sufficient to describe the data, and the estimated half-life was 14.4 h. …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Background The best available treatment against carbapenemase-producing
Enterobacteriaceae (CPE) is unknown. The objective of this study was to investigate the effect of …

… randomly scheduled within three 4 h periods (0800–1200 h, 1200–1600 h, and 1600–2000
h). … In phase 3, median turn-around time was 48 h for chromogenic tests, and 24 h for PCR (…

… first 72 h were characterized as imported from another hospital. The route of acquisition
remained undetermined for patients who were screened for the first time >72 h after admission …

… recent data in critically ill patients receiving continuous venovenous hemodiafiltration
and CMS in reduced doses indicate that colistin C max may well be <1 mg/L (Giamarellou H., …

… CMS was given at a dose of 2.5–5 mg/kg/day intravenously in seven patients, 3.5–10 mg
intrathecally q12 h or every 24 h in two patients, 5–20 mg/day intraventricularly in three patients…