A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic …

N Deng, LK Goh, H Wang, K Das, J Tao, IB Tan… - Gut, 2012 - gut.bmj.com
Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer?

HJ Nyst, IB Tan, FA Stewart, AJM Balm - Photodiagnosis and photodynamic …, 2009 - Elsevier
The mainstay treatments for head and neck carcinomas are surgery, radiotherapy and
chemotherapy. These treatment options may be associated with considerable complications. …

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

…, TKH Lim, EH Tan, W Zhai, DSW Tan, IB Tan… - Nature, 2018 - nature.com
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving
to be effective at restoring T cell-mediated immune responses that can lead to marked and …

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

…, M Wong, PJ Choi, LJK Wee, AM Hillmer, IB Tan… - Nature …, 2017 - nature.com
Intratumoral heterogeneity is a major obstacle to cancer treatment and a significant
confounding factor in bulk-tumor profiling. We performed an unbiased analysis of transcriptional …

Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults: A meta‐analysis and …

IB Tan, KK Ang, BC Ching, C Mohan, CK Toh… - Cancer, 2010 - Wiley Online Library
Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ
cell neoplasia of unclassified type in adults - Tan - 2010 - Cancer - Wiley Online Library …

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

…, A Gan, KH Lim, CK Ong, DC Huang, SY Chin, IB Tan… - Nature …, 2012 - nature.com
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of
somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas …

[HTML][HTML] Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

…, SL Koo, WQ Leow, S Tejpar, S Prabhakar, IB Tan - Nature …, 2022 - nature.com
The consensus molecular subtype (CMS) classification of colorectal cancer is based on
bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …

[HTML][HTML] Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: a JSMO–ESMO initiative endorsed by …

…, K Yamazaki, RH Xu, TW Kim, F Ismail, IB Tan… - Annals of …, 2018 - Elsevier
The most recent version of the European Society for Medical Oncology (ESMO) consensus
guidelines for the treatment of patients with metastatic colorectal cancer (mCRC) was …

[HTML][HTML] Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation

…, B Hermani, S Gondhowiardjo, IB Tan… - Chinese journal of …, 2012 - ncbi.nlm.nih.gov
Among all head and neck (H&N) cancers, nasopharyngeal carcinoma (NPC) represents a
distinct entity regarding epidemiology, clinical presentation, biological markers, carcinogenic …

Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil

Z Lei, IB Tan, K Das, N Deng, H Zouridis, S Pattison… - Gastroenterology, 2013 - Elsevier
Background & Aims Almost all gastric cancers are adenocarcinomas, which have
considerable heterogeneity among patients. We sought to identify subtypes of gastric …