Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of rearrangements …

DEAD‐box proteins are ubiquitous in RNA‐mediated processes and function by coupling
cycles of ATP binding and hydrolysis to changes in affinity for single‐stranded RNA. Many …

RNA-guided nucleases (RGNs) provide sequence-specific gene regulation through base-pairing
interactions between a small RNA guide and target RNA or DNA. RGN systems, which …

Quantitative measurements of biomolecule associations are central to biological
understanding and are needed to build and test predictive and mechanistic models. Given the …

Both scientists and the public would benefit from improved communication of basic scientific
research and from integrating scientists into education outreach, but opportunities to support …

DEAD-box proteins are superfamily 2 helicases that function in all aspects of RNA metabolism.
They employ ATP binding and hydrolysis to generate tight, yet regulated RNA binding, …

High-throughput methodologies have enabled routine generation of RNA target sets and
sequence motifs for RNA-binding proteins (RBPs). Nevertheless, quantitative approaches are …

The mitochondrial DEAD-box proteins Mss116p of Saccharomyces cerevisiae and CYT-19
of Neurospora crassa are ATP-dependent helicases that function as general RNA …

Interactions between RNA and proteins are pervasive in biology, driving fundamental
processes such as protein translation and participating in the regulation of gene expression. …

Posttranslational gene regulation requires a complex network of RNA–protein interactions.
Cooperativity, which tunes response sensitivities, originates from protein–protein interactions …