We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression 1 . Comparative genomics has …

Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification
state can profoundly influence regulation of gene expression. We profiled nucleosome …

PoslTANo , D , HoLwERDA , JB wolters, Gro− 1842 年出版の DUbner の る .Rutherford の ,Didy …
, Swets & Zeitlinger, A 皿 sterdam …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Although the influence of protein binding (PB) on antibacterial activity has been reported for
many antibiotics and over many years, there is currently no standardization for …

Specialized gene expression programs are induced by signaling pathways that act on
transcription factors. Whether these transcription factors can function in multiple developmental …

Background The pan-European VACCELERATE network aims to implement the first
transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry …

The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability
to differentiate into virtually all adult cell types are not well understood. Polycomb group (…

Infection induces platelet activation and consumption, which leads to thrombocytopenia,
enhances microvascular thrombosis, impairs microcirculation and eventually triggers …