Engineering cyanobacteria to generate high-value products

DC Ducat, JC Way, PA Silver - Trends in biotechnology, 2011 - cell.com
Although many microorganisms have been used for the bioindustrial generation of valuable
metabolites, the productive potential of cyanobacterial species has remained largely …

Nuclear transport and cancer: from mechanism to intervention

TR Kau, JC Way, PA Silver - Nature Reviews Cancer, 2004 - nature.com
… There are at least three ways that nuclear transport can be regulated. The first is by
modification of the cargo, which in turn affects its ability to interact with its cognate transporter. …

[HTML][HTML] Integrating biological redesign: where synthetic biology came from and where it needs to go

JC Way, JJ Collins, JD Keasling, PA Silver - Cell, 2014 - cell.com
Synthetic biology seeks to extend approaches from engineering and computation to redesign
of biology, with goals such as generating new chemicals, improving human health, and …

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

JC Way, M Chalfie - Cell, 1988 - cell.com
… Four new mec-3 alleles were identified in this way (see Experimental Procedures), but
none… Injected pTU24 DNA behaved in a similar way. It is our impression that the inheritance …

Programmable bacteria detect and record an environmental signal in the mammalian gut

…, L Siraj, JJ Collins, JC Way… - Proceedings of the …, 2014 - National Acad Sciences
The mammalian gut is a dynamic community of symbiotic microbes that interact with the host
to impact health, disease, and metabolism. We constructed engineered bacteria that survive …

Efficient solar-to-fuels production from a hybrid microbial–water-splitting catalyst system

…, DK Bediako, B Colón, JC Way… - Proceedings of the …, 2015 - National Acad Sciences
Photovoltaic cells have considerable potential to satisfy future renewable-energy needs, but
efficient and scalable methods of storing the intermittent electricity they produce are …

New Tn10 derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition

JC Way, MA Davis, D Morisato, DE Roberts, N Kleckner - Gene, 1984 - Elsevier
We describe below several new variants of the tetracycline-resistance transposon Tn10
which are more useful than the wild-type transposon for many types of genetic and physical …

Rerouting carbon flux to enhance photosynthetic productivity

DC Ducat, JA Avelar-Rivas, JC Way… - Applied and …, 2012 - Am Soc Microbiol
The bioindustrial production of fuels, chemicals, and therapeutics typically relies upon
carbohydrate inputs derived from agricultural plants, resulting in the entanglement of food and …

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types.

JC Way, M Chalfie - Genes & development, 1989 - genesdev.cshlp.org
… A number of genes (eg, mec-4 and mec-7] appear to be selectively expressed in touch
receptor neurons, and we have hypothesized that mec-3 is required for their ex pression (Way

Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation

…, RT Bronson, JW Kotula, GK Gerber, JC Way… - Nature …, 2017 - nature.com
Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut
but commercial translation of technologies to accomplish this has been hindered by the …