After fusion, HIV delivers its conical capsid into the cytoplasm. To release the contained
reverse-transcribing viral genome, the capsid must disassemble in a process termed uncoating. …

Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the
target cell and undergoes a series of trafficking and replicative steps that result in the nuclear …

The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan,
China, with a new coronavirus designated SARS-CoV-2. The principal cause of death from …

Disparities in SARS-CoV-2 genomic surveillance have limited our understanding of the viral
population dynamics and may delay identification of globally important variants. Despite …

We have previously described polyglutamine-binding protein 1 (PQBP1) as an adapter
required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response to the human …

The fate of influenza A virus (IAV) infection in the host cell depends on the balance between
cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of …

Although vaccination efforts have expanded, there are still gaps in our understanding
surrounding the immune response to SARS-CoV-2. Measuring IgG Fc glycosylation provides …

It has been known for a number of years that integration sites of human immunodeficiency
virus type 1 (HIV-1) DNA show a preference for actively expressed chromosomal locations. A …

HIV mainly targets CD4 + T cells, from which Th 17 cells represent a major cell type,
permissive, and are capable of supporting intracellular replication at mucosal sites. Th 17 cells …

Members of the tripartite motif (TRIM) protein family have been shown to assemble into
structures in both the nucleus and cytoplasm. One TRIM protein family member, TRIM5α, has …