The selective localization of protein synthetic machinery at postsynaptic sites makes it
possible for the synthesis of particular proteins to be regulated by synaptic signals. Here we …

T lymphocytes encounter complex mechanical cues during an immune response. The
mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial infections, …

The mRNA for Arc (activity‐regulated cytoskeletal protein) is delivered into dendrites and
localizes selectively at active synapses. Here we use a green fluorescent protein‐based …

… of glomeruli is apparent as early as 2 days postfertilization; three lobes of the map can be
identified which correspond to the central zone, dorsal zone, and medial glomerulus (JL Dynes …

Orai1 comprises the pore-forming subunit of the Ca 2+ release-activated Ca 2+ (CRAC)
channel. When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic …

Strain AK127 is a developmental mutant of Dictyostelium discoideum that was isolated by
restriction enzyme-mediated integration (REMI). Mutant cells aggregate normally but are …

10.7554/eLife.32417.001 Calcium is an essential cellular messenger that regulates numerous
functions in living organisms. Here, we describe development and characterization of ‘…

Stromal interacting molecule (STIM) and Orai proteins constitute the core machinery of store-operated
calcium entry. We used transmission and freeze–fracture electron microscopy to …

T lymphocyte motility and interaction dynamics with other immune cells are vital determinants
of immune responses. Regulatory T (Treg) cells prevent autoimmune disorders by …

We constructed a partial Sau3A Dictyostelium genomic DNA library in a shuttle vector that
replicates extrachromosomally in Dictyostelium cells. This library was used to complement …