To successfully mitigate the extraordinary devastation caused by the Coronavirus disease
2019 (COVID-19) pandemic, it is crucial to identify important risk factors for this disease. One …

Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation.
Here we demonstrate that variants causing haploinsufficiency of KMTs and KDMs are …

We delineate a KMT2E-related neurodevelopmental disorder on the basis of 38 individuals
in 36 families. This study includes 31 distinct heterozygous variants in KMT2E (28 …

The occurrence of non-epileptic hyperkinetic movements in the context of developmental
epileptic encephalopathies is an increasingly recognized phenomenon. Identification of …

Individuals with severe, undiagnosed developmental disorders (DDs) are enriched for damaging
de novo mutations (DNMs) in developmentally important genes. We exome sequenced …

Clinical and epidemiological studies have identified male sex as an important risk factor for
COVID-19 clinical outcomes and mortality. This raises the question as to how this risk factor …

Hemodialysis (HD) patients have a high incidence of hyperlipidemia. Hypertriglyceridemia
is the most frequent abnormality encountered. It results mainly from a defect in the …

Technology advancement is considered the most aggressive among business external forces.
A fact that will impact negatively numerous job categories, among these are accounting …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapeutic agents; however,
their use is hampered by subsequent cardiotoxicity risk. Our understanding of cardiomyocyte …

Background In the early 2000s, two cucurbit-infecting begomoviruses were introduced into
the eastern Mediterranean basin: the Old World Squash leaf curl virus (SLCV) and the New …