High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by
EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing …

… where n ij denotes the number of occurrences of the j-th letter in the i-th column and b j refers
to the background frequency of the j-th letter (Hertz and Stormo, 1999). While this measure …

Systematic Evolution of Ligands by EXponential Enrichment (SELEX) is a well established
experimental procedure to identify aptamers - synthetic single-stranded (ribo)nucleic …

Aptamers, short RNA or DNA molecules that bind distinct targets with high affinity and specificity,
can be identified using high-throughput systematic evolution of ligands by exponential …

The capability of producing and efficiently processing big data has revolutionized virtually
every field of science and technology and has enabled the analysis of experimental results at …

… Mapping these mutations to the predicted secondary structure (Figure 4C) of the #411-J
aptamer did not provide a suitable explanation as to why one but not the other mutation caused …

… We also thank J. Sheldon and S. Richardson for providing scientific insight. … (TTX)-sensitive
and TTX-resistant sodium channels in mammalian sensory neurons J. Biol. Chem. …

With properties such as stability to long-term storage and amenability to repetitive use, nucleic
acid aptamers are compatible with many sensing/transducing platforms intended for use …

Background Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor
(CAR) T cell therapies can benefit from selection of new targets with high levels of tumor …

Peptide macrocyclization is typically associated with the development of higher affinity and
more protease stable protein ligands, and, as such, is an important tool in peptide drug …