Stbd1 is a protein of previously unknown function that is most prevalent in liver and muscle,
the major sites for storage of the energy reserve glycogen. The protein is predicted to contain …

Approximately 90% of cases of Lafora disease, a fatal teenage-onset progressive myoclonus
epilepsy, are caused by mutations in either the EPM2A or the EPM2B genes that encode, …

The glucose storage polymer glycogen is generally considered to be an important source of
energy for skeletal muscle contraction and a factor in exercise endurance. A genetically …

Conversion to glycogen is a major fate of ingested glucose in the body. A rate-limiting
enzyme in the synthesis of glycogen is glycogen synthase encoded by two genes, GYS1, …

Disruption of the Gys2 gene encoding the liver isoform of glycogen synthase generates a
mouse strain (LGSKO) that almost completely lacks hepatic glycogen, has impaired glucose …

In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization.
Under conditions of insulin-induced hypoglycemia, glucagon is the most important …

As metabolic changes in human skeletal muscle after long-term (simulated) spaceflight are
not well understood, this study examined the effects of long-term microgravity, with and …

Glycogen, the repository of glucose in many cell types, contains small amounts of covalent
phosphate, of uncertain function and poorly understood metabolism. Loss-of-function …

Mutations in the ferritin light chain (FTL) gene cause the neurodegenerative disease
neuroferritinopathy or hereditary ferritinopathy (HF). HF is characterized by a severe movement …

The cellular events mediating the pleiotropic actions of portal vein glucose (PoG) delivery on
hepatic glucose disposition have not been clearly defined. Likewise, the molecular defects …